Is the use of Viagra is safe and can be relied on for sexual satisfaction?

Use of Viagra for sex. Does it has any side effects. How can you find the genuine product from the fake available in the market.

Is the use of Viagra is safe and can be relied on for sexual satisfaction?
In the long run, no to both.





Those types of drugs restrict bloodflow, not only in your genetalia but in the fine capillaries in your eyes. They've been linked to vision impairment.





Not only that, but the gear in your underwear is like a little conscience. It knows something you don't. Fix your relationship and "those" problems go away.
Reply:First, it is NOT a recreational drug (meaning take it just to take it). It is marketed for men with specific problems. If you have no problem with male arousal, there is no reason for you to take it.





Get a prescription from your doctor and take it to your local pharmacy. They will have the real stuff and not the fake stuff you see advertised all over the Internet.





As for being safe, that is part of the reason you need to see your doctor first. If you have heart ailments or other problems, it can be dangerous.
Reply:Sildenafil citrate, sold under the names Viagra, Revatio and (in the Indian subcontinent) Caverta, is a drug used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH), developed by the pharmaceutical company Pfizer. Viagra pills, intended to treat impotence, are blue with the words "Pfizer" on one side and "VGR xx" (with xx representing 25, 50 or 100, the dose of that pill in milligrams) on the other.





History


Sildenafil, initially known as compound UK-92,480, was initially developed to treat angina pectoris (a form of cardiovascular disease). Phase I clinical trials suggested that the drug had little effect on angina, but that it could induce marked penile erections. Pfizer therefore decided to market it for erectile dysfunction, rather than for angina. The drug was patented in 1996, approved for use in erectile dysfunction by the FDA on March 27, 1998, becoming the first pill approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year. It soon became a great success: annual sales of Viagra in the period 1999–2001 exceeded $1 billion.





The name "Viagra", like many drug names, is a marketing invention. It was possibly inspired by the Sanskrit word "vyāghra", which means "tiger". The word rhymes with "Niagara" (Niagara Falls is a popular honeymoon destination and Niagara, being such an impressive cataract, evokes a sense of incredible erectile and ejaculatory strength). The sound of the word also suggests the words "vigor" and "virile".





Even though Viagra is only available by prescription from a doctor, it was advertised directly to consumers on TV (famously being endorsed by Bob Dole). Numerous sites on the Internet offer Viagra for sale after an "online consultation," a mere web questionnaire. The "Viagra" name has become so well known that many fake aphrodisiacs now call themselves "herbal Viagra" or are presented as blue tablets imitating the shape and colour of Pfizer's product. A mixture of Viagra and ecstasy, called sextasy, has become popular among rave partygoers. Viagra is also informally known as "Vitamin V", "the Blue Pill", and goes by various other nicknames.





It has been suggested that Viagra would lead to a marked drop in the demand for certain traditional remedies, such as tiger penises and rhinoceros horns and that the drug may therefore help to preserve these endangered species. However, this is unlikely in that these parts of endangered species are not only used to treat impotence. Rhinoceros horns, for example, are used as a treatment for high fever. Furthermore, since Viagra has not been shown to possess aphrodisiac properties, it is unclear that the natural remedies would compete with this new clinical drug.





Pfizer's worldwide patents on sildenafil citrate will expire in 2011–2013. The UK patent held by Pfizer on the use of PDE5 inhibitors (see below) as treatment of impotence has been invalidated in 2000 because of obviousness; this decision was upheld on appeal in 2002.





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Mechanism of action


Part of the physiological process of erection involves the parasympathetic nervous sytem to release nitric oxide (NO) in the corpus cavernosum of the penis. NO binds to the receptors of the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation (vasodilation) in the corpus cavernosum, resulting in increased inflow of blood and an erection.





Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of cGMP in the corpus cavernosum, resulting in better erections. Without sexual stimulation and no activation of the NO/cGMP system, sildenafil should not cause an erection. Other drugs that operate by the same mechanism include tadalafil (Cialis®) and vardenafil (Levitra®).





Sildenafil is metabolised by hepatic enzymes and excreted by both the liver and kidneys. If taken with a high fat meal, there may be a delay in absorption of sildenafil and the net effect might be muted slightly as the plasma concentration will be lowered.





Some reports have claimed that sildenafil causes enhanced sexual pleasure for women by increasing blood flow to the sexual organs.





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Dosage and price


As with all prescription drugs, proper dosage is at the discretion of a licensed medical doctor. The dose of sildenafil is 25 mg to 100 mg taken once per day between 0.5 to 4 hours before sexual intercourse.





It is usually recommended to start with a dosage of 50 mg and then lower or raise the dosage as appropriate. The drug is sold in three dosages (25, 50, and 100 mg), all three costing about USD$10 per pill. Sildenafil is not scored, meaning there is no guarantee that the drug is evenly distributed throughout the tablet, therefore it is not advisable to cut it to change dosage.





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Contraindications and side effects


Contraindications include:





When taking other nitric oxide donors, organic nitrites and nitrates, such as glyceryl trinitrate, sodium nitroprusside, amyl nitrite ("poppers") (Cheitlin et al 1999)


In men for whom sexual intercourse is inadvisable due to cardiovascular risk factors


Severe hepatic impairment (decreased liver function)


Severe impairment in renal function


Hypotension (low blood pressure)


Recent stroke or heart attack


Hereditary degenerative retinal disorders (including genetic disorders of retinal phosphodiesterases)


Amongst sildenafil's serious adverse effects are: priapism, severe hypotension, myocardial infarction, ventricular arrhythmias, sudden death, stroke and increased intraocular pressure.





Common side effects include sneezing, headache, flushing, dyspepsia, prolonged erections, palpitations and photophobia. Visual changes including blurring of vision and a curious bluish tinge have also been reported.





In May of 2005, the U.S. Food and Drug Administration found that sildenafil could lead to vision impairment. An investigation is currently underway. Some patients developed nonarteritic ischemic optic neuropathy (NAION), an eye problem that can result in permanent vision loss. Combined with past reports, this study brings the total number of sildenafil-related NAION cases to 14.





Some users complained of blurriness and some a loss of peripheral vision. It appears that there is a hereditary condition described as a "cup" in the retina that is the constant among all cases.





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Uses outside of erectile dysfunction


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Pulmonary hypertension


Studies have shown that apart from in erectile dysfunction, sildenafil citrate is also effective in the rare disease pulmonary arterial hypertension (PAH). It appears to relax the arterial wall, decreasing the pressure on the lung vasculature and improving symptoms of right-sided heart failure. Due to the distribution of PDE-5, which is primarily in the smooth muscle of the lungs and penis, sildenafil acts selectively in both these areas without inducing vasodilation in other areas of the body. As a result of these studies, Pfizer submitted an additional registration for sildenafil with the FDA, and was approved for this indication in June 2005. Presumably to avoid confusion with Viagra, the preparation is named Revatio and the 20 milligram tablets are white and round. Sildenafil follows bosentan and prostacyclin as therapies for this condition.





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Raynaud's phenomenon


In 2005, Dr. Roland Fries and colleagues reported that sildenafil cut the frequency of Raynaud's phenomenon attacks, reduced their duration by roughly one half, and more than quadrupled the mean capillary blood velocity. This was a double-blind, placebo-controlled crossover trial and the patients had both the primary and secondary forms and had all discontinued the more conventional treatments for this (Fries et al 2005). It had earlier been reported to be effective for Raynaud's in a 65-year-old woman with scleroderma and pulmonary hypotension (Rosenkranz et al 2003); (Rosenkranz et al 2004), and in nine women and one man treated by a Dr. Jack R. Lichtenstein of Annapolis, Maryland over a three-year period (Lichtenstein 2003).
Reply:I've tried Viagra. It certainly worked for me, man! Woo-hoo! But I used it to see what would happen, not for any disfunction. I was hard for two days, and had several orgasms.


Great, good times! (Can't wait until I get old and crusty and can use it all the time!)